RESUMO
The distribution of lipids in accessory sex glands of male rats (immature, adult and castrated) has been analysed. The total lipids and phospholipids in adult rats were maximum in caput epididymis and minimal in prostate. An intermediary picture existed in the cauda epididymis and seminal vesicle. In general, phosphatidyl choline and ethanolamine were the major phospholipids in the tissues. Castration depleted the phospholipids in all the tissues. Glycerides were found to accumulate in caput and cauda epididymis, but were depleted in seminal vesicle and prostate in castrated rats. In immature rats, the total lipids were more than that of adults in caput and cauda epididymis but were less in seminal vesicle and prostate. It is suggested that these discrepancies may be due to the differences in the endogenous titres of hormones, and/or associated with structural and functional specificity of the tissues.
Assuntos
Envelhecimento , Animais , Castração , Epididimo/metabolismo , Genitália Masculina/metabolismo , Metabolismo dos Lipídeos , Masculino , Fosfolipídeos/metabolismo , Próstata/metabolismo , Ratos , Ratos Endogâmicos , Glândulas Seminais/metabolismoAssuntos
Antagonistas de Androgênios/farmacologia , Animais , Colesterol/metabolismo , Ciproterona/farmacologia , Relação Dose-Resposta a Droga , Genitália Masculina/metabolismo , Glicerídeos/metabolismo , Metabolismo dos Lipídeos , Masculino , Medroxiprogesterona/farmacologia , Fosfolipídeos/metabolismo , RatosRESUMO
The normal pattern of lipids during various phases of estrous cycle in different reproductive tissues of female rats was analysed. The various lipid calsses undergo striking cyclical changes in harmony with the rhythm of endogenous gonadal and gonadotrophic hormones. A comparison of lipid pattern was made between various phases of estrous cycle. Ovary exhibited marked alterations in the distribution of lipids in different phases of the cycle compared to other tissues. Total lipids were maximum in diestrus phospholipids in estrus with a concomittant fall in triglycerides in all the tissues. The fluctuation in oviductal and vaginal lipids was much less compared to other tissues. Hormone-lipid interrelationship and tissue specificity may be attributed to these changes.
Assuntos
Animais , Diestro , Estro , Tubas Uterinas/metabolismo , Feminino , Genitália Feminina/metabolismo , Metabolismo dos Lipídeos , Metestro , Ovário/metabolismo , Gravidez , Proestro , Ratos , Útero/metabolismo , Vagina/metabolismoRESUMO
Administration of testosterone, oestrogen, progesterone and prolactin for seven days affected the epididymal lipids markedly whereas seminal vesicular and prostatic lipids were less affected. The increase in total lipids of caput epididymis by testosterone, oestrogen and progesterone was due to an elevation in neutral and phospholipid contents. However, progesterone alone caused an increase in total lipids of the cauda epididymides while oestrogen and prolactin decreased the same. In seminal vesicle and prostate, testosterone elicited a significant rise in total lipids. However, an opposite trend was obvious by the other three hormones. Testosterone alone was effective in elevating the total lipids, phospholipid, cholesterol and glycerides in prostates. Prolactin does not affect the prostatic lipids markedly. The significance of the lipid changes are discussed in relation to various physiological activities of sex accessories.